Dr Shirota’s objective was to isolate a beneficial bacterium that would be able to survive through our stomach and bile acids to arrive alive in our intestines. There it would assist the functioning of our digestive system. Subsequently, he discovered that lactobacilli could also destroy harmful bacteria that live in our intestines. Excited by this finding, he conducted an exhaustive investigation of lactobacilli, whereupon he discovered a new strain of bacteria.
This strain of bacteria - Lactobacillus casei, was found to be the most acid and bile resistant and was subsequently named Lactobacillus casei Shirota strain in honor of Dr Shirota’s research. It was the discovery of this bacterium that led to the birth of Yakult.
Dr Shirota’s objective was to isolate a beneficial bacterium that would be able to survive through our stomach and bile acids to arrive alive in our intestines. There it would assist the functioning of our digestive system. Subsequently, he discovered that lactobacilli could also destroy harmful bacteria that live in our intestines. Excited by this finding, he conducted an exhaustive investigation of lactobacilli, whereupon he discovered a new strain of bacteria.
This strain of bacteria - Lactobacillus casei, was found to be the most acid and bile resistant and was subsequently named Lactobacillus casei Shirota strain in honor of Dr Shirota’s research. It was the discovery of this bacterium that led to the birth of Yakult.

The Yakult Central Institute for Microbiological Research
Established in 1967 by Dr Shirota, the Yakult Research Institute is located in Tokyo, Japan. Its primary function is to investigate the use of beneficial bacteria in the promotion of health.
Today, over 170 research scientists and medical doctors are actively pursuing research aimed at applying bacteria effectively in the prevention and treatment of many diseases.
Yakult works closely with the scientific and medical communities, organizing conferences and funding research, all to increase understanding of the role of beneficial bacteria in health.
The pioneer of fermentation lactobacilli milk drinks
Dr Shirota’s objective was to isolate a beneficial bacterium that would be able to survive through our stomach and bile acids to arrive alive in our intestines. There it would assist the functioning of our digestive system. Subsequently, he discovered that lactobacilli could also destroy harmful bacteria that live in our intestines. Excited by this finding, he conducted an exhaustive investigation of lactobacilli, whereupon he discovered a new strain of bacteria.
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